Publications by authors named "P H Jarreau"
Unlabelled: The short-term respiratory consequences of small for gestational (SGA) are only partially known. Our aim was to compare the early respiratory features between SGA and appropriate for gestational age (AGA) in very preterm infants. We conducted a secondary analysis of the French prospective EPIPAGE-2 cohort.
View Article and Find Full Text PDFProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics.
Genomics Proteomics Bioinformatics
November 2024
Article Synopsis
- Mass spectrometry (MS) is a key technique used for identifying and understanding proteins, which is important for fields like personalized medicine and systems biology.
- The development of ProtPipe aims to simplify MS data analysis by automating processes like data quality control, sample filtering, and normalization, making it easier to handle complex datasets.
- ProtPipe also offers various downstream analyses, such as identifying differences in protein abundance and visualizing interactions, and is available as an open-source tool with a user-friendly interface at https://github.com/NIH-CARD/ProtPipe.
Article Synopsis
- - The paper explores using Large Language Models (LLMs) to streamline data wrangling and automate tasks in data discovery and harmonization, crucial for making biomedical data AI-ready by developing Common Data Elements (CDEs).
- - A human-in-the-loop approach was utilized to ensure the accuracy of generated CDEs from various studies and databases, achieving a high accuracy rate where 94.0% of fields required no manual changes, with an interoperability mapping rate of 32.4%.
- - The resulting CDEs are designed to improve dataset compatibility by measuring how well different data sources align with these standards, ultimately enhancing the efficiency and scalability of biomedical research efforts.
Unlabelled: Thrombocytopenia is common in preterm neonates and can be associated with hemorrhage. Most platelet transfusions are prophylactic. Previously, higher platelet-count thresholds were recommended for neonates, but this recommendation has been questioned in recent studies.
View Article and Find Full Text PDFArticle Synopsis
- A study examined the prevalence and incidence of interstitial lung disease in children (chILD) in France, finding it affects 44 children per million in 2022 and has an incidence of 4.4 per million.
- The research included data from 790 patients across 42 centers, noting that the median age for diagnosis was 3 months, with a significant portion having familial forms.
- Management typically involved oxygen therapy and corticosteroids, with survival rates being 57.3% for children diagnosed before 2 years and 86% for those diagnosed between 2 and 18 years; the study highlights the need for improved international data collection and standardized practices.