Publications by authors named "P H Hasler"
Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. We have designed a dual adeno-associated viral vector encoding a split-intein adenine base editor to correct the most common mutation in ABCA4 (c.5882G>A, p.
View Article and Find Full Text PDFPurpose: To investigate the clinical outcomes of micropulse transscleral laser therapy (MP-TLT) in a cohort of glaucoma patients, including safety profile, post-operative transient intraocular pressure (IOP) spikes, long-term efficacy and prognostic factors in terms of IOP-lowering.
Methods: This was a retrospective observational cohort study. Medical records of all patients who consecutively underwent MP-TLT between May 2019 and February 2023 at a tertiary referral centre were scrutinised and relevant data were retrospectively analysed.
Purpose: Epiretinal membranes (ERM) pose a common challenge in vitreoretinal pathology, often causing vision impairment in older adults. The Preceyes Surgical System (PSS) supports the surgical removal of ERM through robot-assisted membrane peeling (RA-MP). This study compares surgical times and iatrogenic hemorrhages between manual membrane peeling (MMP) and RA-MP using PSS.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on treatment patterns for systemic sclerosis patients in Switzerland, particularly those with fibrotic symptoms, using data from the EUSTAR registry.
- - A total of 590 patients were included, revealing that 71.4% had skin issues and 43.4% had interstitial lung disease, with a portion showing extensive complications.
- - The most commonly prescribed non-biologic treatments were methotrexate and hydroxychloroquine, while rituximab and tocilizumab were the leading biologic options administered to patients with skin fibrosis.