The lived experience of patients with bipolar disorder with adapting their lifestyle to their condition.

Background: An important element of self-management strategies for people with bipolar disorder is adapting their lifestyle to their condition, since this improves their quality of life. However, not all people with bipolar disorder succeed in lifestyle adaptation. Knowledge about their lived experience with adaptation would enhance understanding about how healthcare providers optimize support.

Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics.

Macrophage infiltration and accumulation in the atherosclerotic lesion are associated with plaque progression and instability. Depletion of macrophages from the lesion might provide valuable insights into plaque stabilization processes. Therefore, we assessed the effects of systemic and local macrophage depletion on atherogenesis.

Women's Experiences With a Pregnancy Relapse Prevention Plan to Prevent Mental Health Symptom Relapse.

Objective: To describe the experiences of women with a mental health diagnosis with making and using a pregnancy relapse prevention plan (PRPP) in an effort to prevent mental health symptom relapse during the period of pregnancy, birth, and postpartum.

Design: Qualitative design with a phenomenological approach.

Setting: Participants were recruited from an outpatient clinic within a "psychiatry and pregnancy" mental health institute in the Netherlands.

Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability.

Background: Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including endothelial cells, smooth muscle cells, and inflammatory cells. However, a comprehensive analysis of metabolic changes associated with the transition of plaque from a stable to a hemorrhaged phenotype is lacking.

Methods: In this study, we integrated two large mRNA expression and protein abundance datasets (BIKE, n = 126; MaasHPS, n = 43) from human atherosclerotic carotid artery plaque to reconstruct a genome-scale metabolic network (GEM).

Comparison of Soft Indicator and Poisson Kriging for the Noise-Filtering and Downscaling of Areal Data: Application to Daily COVID-19 Incidence Rates.

This paper addresses two common challenges in analyzing spatial epidemiological data, specifically disease incidence rates recorded over small areas: filtering noise caused by small local population sizes and deriving estimates at different spatial scales. Geostatistical techniques, including Poisson kriging (PK), have been used to address these issues by accounting for spatial correlation patterns and neighboring observations in smoothing and changing spatial support. However, PK has a limitation in that it can generate unrealistic rates that are either negative or greater than 100%.