Interaction of the endogenous antibody response with activating FcγRs enhance control of Mayaro virus through monocytes.

Mayaro virus (MAYV) is an emerging arbovirus. Previous studies have shown antibody Fc effector functions are critical for optimal monoclonal antibody-mediated protection against alphaviruses; however, the requirement of Fc gamma receptors (FcγRs) for protection during natural infection has not been evaluated. Here, we showed mice lacking activating FcγRs (FcRγ-/-) developed prolonged clinical disease with increased MAYV in joint-associated tissues.

Forced to Live: Controlled Forced Feeding of Political Prisoners and the Challenge to Nation-States' Civilising Processes.

Since the nineteenth century, struggles between state power and political prisoners' right to die have aroused considerable interest. State enforcement to 'make live' through force-feeding also raises important questions concerning processes that inform government approaches, often through methods considered to be brutal, and how these actions fit within perceptions of civilised behaviour. The social scientific focus of hunger strikes tends to be informed by Foucauldian bio-power and governmentality which we draw upon when applying insights from figurational sociology.

Novel reporter constructs to accelerate antiviral and therapeutic discovery for Enterovirus-A71.

Enterovirus A71 (EV-A71) is an important human pathogen and 'prototype pathogen' for studies of other Enteroviruses of pandemic potential. Understanding the biology of EV-A71 would inform generalizable strategies for antiviral drug, vaccine, and monoclonal antibody development. Such studies are accelerated by robust reagents to evaluate efficacy.

Evaluating an urgent care antibiotic stewardship intervention: a multi-network collaborative effort.

Objective: Urgent care centers (UCCs) have reported high rates of antibiotic prescribing for acute respiratory tract infections. Prior UCC studies have generally been limited to single networks. Broadly generalizable stewardship efforts targeting common diagnoses are needed.