Publications by authors named "P H Dennehy"

Article Synopsis
  • The study aimed to investigate whether starting valganciclovir treatment after one month of age could enhance hearing in children with congenital cytomegalovirus-associated hearing loss.
  • Researchers conducted a randomized, double-blind trial involving 54 participants aged 1 month to 3 years, comparing the effects of 6 weeks of valganciclovir versus a placebo on hearing outcomes and viral load.
  • Results showed no significant improvement in hearing for the treatment group compared to the placebo, despite a notable reduction in viral load, indicating that starting treatment later does not effectively improve hearing in affected children.
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A diagnosis of multisystem inflammatory syndrome in children should be made in the appropriate context and after ruling out other infectious causes. At the same time, clinicians should be diligent as the initial presentation can be unusual and the clinical picture can evolve over time. We report a case that was initially diagnosed as a retropharyngeal infection that did not improve on appropriate antimicrobial coverage.

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The danger of vaccine hesitancy is perhaps one of the most critical challenges we face as practitioners. This riveting narrative helps us find common ground and courage as it reaches into the hearts of those of us who have encountered parents who also want what's best for their child.

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Background: Systems for standardizing physician payment have been shown to undervalue cognitive clinical encounters. Because health care reform emphasizes value-based approaches, we need an understanding of the way pediatric cognitive specialties are used to contribute to the provision of high-value care. We sought to investigate how clinical and administrative stakeholders perceive the value of pediatric infectious disease (PID) specialists.

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Background: Vancomycin is frequently used to treat methicillin-resistant Staphylococcus aureus infections in pediatric patients. Vancomycin exposure may lead to an increase in frequency of nephrotoxicity. Our aim was to conduct a systematic review to describe predictors of nephrotoxicity associated with vancomycin, including documented trough concentrations ≥15 mg/L.

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