Timing of intermittent seminal HIV-1 RNA shedding in patients with undetectable plasma viral load under combination antiretroviral therapy.

It was demonstrated that combination antiretroviral therapy (cART) reduces the HIV-1 viral load (VL) in the blood and the seminal compartment. Some studies have reported that the seminal HIV-1 VL is undetectable in individuals with an undetectable blood plasma viral load (bpVL) under cART. However, some recent studies have demonstrated that seminal HIV-1 RNA may still be detected, and potentially infectious, even in the case of an undetectable bpVL.

[The process of X inactivation in the mouse].

X chromosome inactivation (XCI) is an excellent model for studying how epigenetic marks are initiated during early embryogenesis. XCI is an essential process that takes place in females, leading to dosage compensation between males and females. In mouse, it occurs in two waves: the first one is paternally imprinted, during the preimplantation period and the second one occurs in a random fashion.

[Pregnancy predictive factors in case of double embryo transfer during "Top Quality" attempts].

Objectives: To identify IVF±ICSI pregnancy predictive factors during "Top Quality" attempts in case of double embryo transfer.

Patients And Methods: Three years retrospective study (2007, 2008 and 2009) on parameters and results obtained during IVF±ICSI defined as "Top Quality" attempts: first or second attempts on less than 35years old women (age inferior or equal to) with one or two "Top Quality" embryo transfer.

Results: In case of double embryo transfer, pregnancy predictive factors are (OR [IC 95%], P): average endometrial thickness on start (4.

[Professional Practice Evaluation: How to improve quality management in procreation centers?].

Objectives: The Professional Practice Evaluation (PPE) is at the heart of quality management in procreation centers. Hereby, we report 3 years of EPP in Cytogenetics and Reproduction laboratory in Amiens University Hospital.

Patients And Methods: This PPE is based upon prospective analysis of in vitro fertilization techniques regarding two major parameters: clinically in improving embryo transfer and biologically by determining fecundation levels.