Publications by authors named "P H Byers"
We assessed severe acute respiratory syndrome coronavirus 2 seroprevalence on residual blood samples for pediatric COVID-19 surveillance: 2263 samples were collected during routine outpatient visits (<18 years, April 2020-August 2021). Seroprevalence increased over time, coinciding with or preceding virus circulation in the community and with or preceding pediatric severe COVID-19 hospitalization peaks. Residual blood sample seroprevalence may be a useful surveillance tool in future outbreaks.
View Article and Find Full Text PDFThe Natural History of Dermatosparaxis Ehlers Danlos Syndrome: An Adult Case Series.
Am J Med Genet A
December 2024
Dermatosparaxis Ehlers Danlos syndrome (dEDS) is a very rare monogenic EDS that occurs due to biallelic pathogenic variants in ADAMTS2. Fifteen individuals with dEDS have been reported in the literature, with the oldest being 19 years at follow-up. Given the lack of information regarding adults with dEDS, our aim was to describe adults with dEDS to inform management recommendations in adulthood.
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- The study develops a high-throughput assay to measure peptides from type III procollagen in human serum, addressing limitations of existing immunoassays used for growth hormone detection.
- The new method utilizes a combination of immunoaffinity enrichment and ultra-high-performance liquid chromatography-tandem mass spectrometry, resulting in good accuracy and precision for quantifying the peptides.
- While this method shows a decent correlation to a standard immunoassay, significant bias indicates a need for standardized calibrators to improve result consistency across different laboratories.
Elective root replacement increases the risk of type B dissection in patients with Marfan syndrome.
J Thorac Cardiovasc Surg
September 2024
Article Synopsis
- Marfan syndrome increases the risk of aortic dissection, and aortic root replacement with Dacron is a common treatment to mitigate this risk, though its impact on distal aortic disease is uncertain.
- A study involving 322 adult patients with Marfan syndrome investigated the outcomes of 124 patients who underwent root replacement versus 198 who did not, using various statistical tests over a median follow-up of nearly 10 years.
- Results showed that those who had root replacement had a significantly higher frequency of type B aortic dissection and associated aortic-related mortality, indicating the need for careful monitoring of the distal aorta in these patients.
We combine two-photon-excited fluorescence microscopy and acoustofluidic trapping in a spherical microchamber to study cells and cell clusters three-dimensionally close to conditions. The two-photon microscopy provides the in-depth 3D analysis of the spherical microchamber dimensions as well as the positions of trapped samples therein with high spatial precision and high temporal resolution enabling even tracking of the fast moving particles. Furthermore, optical sectioning allows to gather information of individual cells in trapped cell clusters inside the chamber.
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