Publications by authors named "P H Astoul"

Background: CT-guided trans-thoracic lung biopsy (CT-TTLB) is efficient and widely used to diagnose pulmonary nodules. After pneumothorax, the second most frequent complication is hemoptysis, which can be life-threatening. These patients often have comorbidities and are on acetylsalicylic-acid (ASA) therapy.

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Introduction: Ultrasound-guided trans-thoracic needle biopsy (US-TTNB) is a method of choice for the diagnostic management of peripheral lung lesions and pleural masses for pulmonologists. If complication risk factors and diagnostic yield have been well reported for CT-guided biopsies, publications for US-TTNB in this field are very scarce.

Methods: The primary objective of this study was to describe the diagnostic yield of US-TTNB carried out by pulmonologists defined by a definitive histopathological diagnosis.

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Objective: The main objective of this study was to describe the translation, cultural adaptation, and content validation process of the French National Surveillance Programme for Pleural Mesothelioma (FNSPPM) questionnaire for the Portuguese context.

Methods: A search was conducted in the PubMed database and Web of Science, in the period from January 1, 1960, to December 31, 2022, to select the questionnaire. Forward and reverse translations, calculation of the content validity index (CVI) by a panel of experts ( = 9), and cognitive interviewing with individuals with at least one exposure to asbestos ( = 10) were performed.

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Article Synopsis
  • - Pleural diseases, particularly malignant pleural mesothelioma (PM), pose significant global health challenges, affecting about one million people annually, primarily linked to asbestos exposure and often lead to poor patient outcomes.
  • - Timely and accurate diagnosis of PM is critical but complicated by the need for skilled operators and adequate facilities; traditional methods like cytology aren’t effective, making tissue biopsies essential for accurate diagnosis.
  • - Medical thoracoscopy (MT) and video-assisted thoracoscopy (VATS) are considered the gold standards for diagnosing malignant pleural conditions, enabling both diagnostic and therapeutic interventions, while emphasizing the importance of interdisciplinary collaboration for optimal patient care.
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Article Synopsis
  • Malignant pleural effusions (MPE) are common in cancer patients and can greatly impact life expectancy, making effective palliative care essential for improving quality of life and reducing breathlessness.
  • A combined approach using talc poudrage and indwelling catheter placement shows promise in overcoming challenges associated with both techniques, such as extended hospital stays and low pleurodesis success rates.
  • In a study of 25 patients, this combined method achieved an 86% success rate for pleurodesis at six months, with an average hospital stay of only 3.24 days and minimal complications, suggesting it could be a viable treatment option for recurrent MPE.
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