[Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders].

Aim: To reveal platelet functional changes manifesting as abnormal rate of platelet aggregation in patients with acute cerebral circulatory disorders (ischemic stroke, transient ischemic attack), to evaluate the effect of homocysteine (Hc) on platelet aggregation, depending on the degree of cerebral blood flow disturbances, patients' gender and age, and to estimate the diagnostic value of their associations.

Subjects And Methods: 50 patients aged 33 to 98 years (mean age, 63.7 +/- 2.

[A study of biological fluids by ultrasound coagulography].

A new methodology: the method and technical means for studying the coagulation of blood and the acoustic properties of other biological fluids (ultrasound coagulography) was developed. The complex of devices is based on the principle of measuring the rate of ultrasound in a medium studied by means of the impulse method. Arguments for the applicability of the method for studying the process of blood coagulation are adduced, special acoustic chambers were designed, and algorithms and computer programs for immediate processing of the data were developed.

[Atypical creatine phosphokinase isoenzyme fraction in the diagnosis of acute myocardial infarction].

A study of CPK isoenzyme spectrum in acute myocardial infarction, using electrophoresis and isoelectric focusing techniques, demonstrated the possibility of an earlier detection of myocardial necrosis on the basis of changes in CPK MM subzones, rather than the CPK MB test. This approach does not increase the specificity of isoenzyme CPK assays, but improves the reliability of biochemical assessment of the time of onset and depth of myocardial affection.

[Ultrasonic coagulometry as a method of testing compounds with antiplasmin activity].

An ultrasonic interferometer has been used to study the process of fibrin clot lysis according to the decrease in the rate of propagation of an ultrasonic wave in the latter. A significant decrease in the sound fall rate on adding epsilon-aminocaproic and trans-4-aminomethylcyclohexanecarbonic acids to the system indicates their activity inhibiting fibrinolysis. N-nicotinoyl derivatives of this compounds possess less pronounced antiplasmin activity.