Publications by authors named "P Graham Barton"

Recent conceptual and empirical developments in decomposition research have highlighted the intricate dynamics within necrobiome communities and the roles of various decay drivers. Yet the interactions between these factors and their regulatory mechanisms remain relatively unexplored. A comprehensive understanding of this facet of decomposition science is important, given its broad applicability across ecological and forensic disciplines, and current lack of research which investigates the inter-dependencies between two critical components of the necrobiome (the microbiome and insect activity), and the consequences of this interdependency on mass loss and total body score.

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Objectives: Left Ventricular Assist Devices (LVADs) for destination therapy (DT) are used in many countries but in some, like the UK, LVADs are not commissioned due to uncertainty around their cost-effectiveness. Existing economic evaluations of LVADs for these patients have limitations. This study aimed to estimate the cost-effectiveness of LVADs as destination therapy, compared to optimal medical therapy, in the UK.

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Runaway electrons, accelerated in a tokamak discharge to high energies (tens of MeV), can cause serious damage to plasma facing components. Therefore, it is important to develop effective mitigation strategies to reduce the risk of tokamak damage. To study the effects of various mitigation strategies, a dedicated diagnostic, the calorimetry probe, was developed at the COMPASS tokamak.

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  • Dilated cardiomyopathy (DCM) is a major cause of heart failure, and this study analyzes genetic factors by examining 14,256 DCM cases and 36,203 participants from the UK Biobank for related traits.
  • Researchers discovered 80 genomic risk loci and pinpointed 62 potential effector genes tied to DCM, including some linked to rare variants.
  • The study uses advanced transcriptomics to explore how cellular functions contribute to DCM, showing that polygenic scores can help predict the disease in the general population and emphasize the importance of genetic testing and development of precise treatments.
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  • Interleukin 11 (IL11) was initially developed as a treatment for low platelet levels but has shown serious cardiac side effects, prompting researchers to investigate its toxic effects on heart cells for the first time.
  • The study involved injecting recombinant IL11 into mice and using various scientific techniques to assess its effects on heart function and gene expression, revealing drastic reductions in heart performance and increased activation of inflammatory pathways.
  • Findings from cardiomyocyte-specific knockout mouse models showed that IL11 directly induces stress responses and gene expression changes in heart cells, further solidifying its role in heart toxicity rather than protection.
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