Publications by authors named "P Gradisek"
Assessing quality of care is essential for improving the management of patients experiencing traumatic brain injury (TBI). This study aimed at devising a rigorous framework to evaluate the quality of TBI care provided by intensive care units (ICUs) and applying it to the Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe (CREACTIVE) consortium, which involved 83 ICUs from seven countries. The performance of the centers was assessed in terms of patients' outcomes, as measured by the 6-month Glasgow Outcome Scale-Extended (GOS-E).
View Article and Find Full Text PDFArticle Synopsis
- Traumatic brain injury (TBI) does not significantly increase plasma levels of phosphorylated tau at serine-181 (p-tau181) within a year post-injury, unlike Alzheimer's disease where p-tau181 is elevated.* -
- In contrast, other biomarkers like total-tau (t-tau), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) were significantly elevated following TBI and were predictive of brain atrophy rates.* -
- The study highlights that while p-tau181 is a relevant marker in Alzheimer's, it doesn't serve as an indicator of neurodegeneration after moderate-to-severe TBI.*
Importance: While the relationship between persistent elevations in intracranial pressure (ICP) and poorer outcomes is well established for patients with traumatic brain injury (TBI), there is no consensus on how ICP measurements should drive treatment choices, and the effectiveness of ICP monitoring remains unknown.
Objective: To evaluate the effectiveness of ICP monitoring on short- and mid-term outcomes of patients with TBI.
Design, Setting, And Participants: CREACTIVE was a prospective cohort study that started in March 2014 and lasted 5 years.
Article Synopsis
- Traumatic brain injury (TBI) is linked to chronic neurodegeneration, potentially due to systemic inflammation signaling the brain and activating microglia, which can lead to widespread brain damage.
- The study, TBI-braINFLAMM, will analyze data from two major TBI research projects—CREACTIVE and BIO-AX-TBI—to assess the relationship between systemic inflammation, injury severity, and ongoing neurodegeneration.
- Ethical approval has been obtained, and findings will be shared through peer-reviewed publications and conferences to enhance understanding and inform future research in this area.
Background: Critical care medicine is a young branch of medicine, of which the development was much faster in High Income Countries (HICs) than in Low Resources Settings (LRS). Slovenia, as one of the successor states of former Yugoslavia, passed the process of transition and joined the European Union successfully. On the contrary, Bosnia and Herzegovina (B&H) went through the extremely difficult process of transition (four years of civil war), which left a deep scar to the healthcare system, including critical care medicine.
View Article and Find Full Text PDF