Past, Present and Future of the European Chemical Society (EuChemS).

50 years of EuChemS: In this Guest Editorial, F. Rutjes, EuChemS President-Elect, and P. Goya, EuChemS President, provide a brief overview of the history of the European Chemical Society and of what has been achieved over the past decades as well as an impression of the challenges that lie ahead.

Timed immersion expiration measures in patients with muscular dystrophies.

Introduction: Muscular dystrophies (MD) cause muscle weakness, affecting motor and respiratory functions. Aquatic activities maintain strength and ventilatory function and may require immersion expiration control.

Objectives: (1) To describe the evolution of timed immersion expiration in patients with MD in one-year follow-up.

Emerging strategies targeting CB cannabinoid receptor: Biased agonism and allosterism.

During these last years, the CB cannabinoid receptor has emerged as a potential anti-inflammatory target in diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, ischemic stroke, autoimmune diseases, osteoporosis, and cancer. However, the development of clinically useful CB agonists reveals to be very challenging. Allosterism and biased-signaling mechanisms at CB receptor may offer new avenues for the development of improved CB receptor-targeted therapies.

Responsiveness of the Gait Domain of the Functional Evaluation Scale for Children with Duchenne Muscular Dystrophy.

Aim: To determine the responsiveness of functional gait assessment of children with Duchenne muscular dystrophy (DMD).

Method: A total of 160 films of 32 children (mean age: 9.5 ± 2.

Study of Meldrum's Acid Cyclization Reactions.

On the basis of the cyclization reactions reported by Danishefsky et al. of Meldrum's acid hydroxylethyl and anilinoethyl derivatives, the cyclization of the sulfamidomethylene and ureidomethylene derivatives was attempted without success. To understand the lack of reactivity of these compounds versus the successful cyclization of the ethyl derivatives, the corresponding mechanisms of reaction for both processes have been explored by means of MP2/6-311+G(d,p) calculations in an aqueous environment.