Publications by authors named "P Gowtham"
Article Synopsis
- - The study examined the toxic effects of the ethanolic extract of Passiflora incarnata (EEP) and its nanoformulation (N-EEP) in both lab models, specifically zebrafish embryos and Swiss albino mice, confirming their composition through phytochemical analysis.
- - In vitro tests showed that both EEP and N-EEP affected normal lung cells in a dose-dependent manner, while no developmental issues were seen in zebrafish embryos at a concentration of 200 µg/ml.
- - Acute and sub-acute toxicity tests in mice revealed that doses below 600 mg/kg of EEP and N-EEP can be considered safe for treating various diseases, as evidenced by observed physiological parameters and histopathological analyses
Introduction: As cancer therapy progresses, challenges remain due to the inherent drawbacks of conventional treatments such as chemotherapy, gene therapy, radiation therapy, and surgical removal. Moreover, due to their associated side effects, conventional treatments affect both cancerous and normal cells, making photodynamic therapy (PDT) an attractive alternative.
Methods: As a result of its minimal toxicity, exceptional specificity, and non-invasive characteristics, PDT represents an innovative and highly promising cancer treatment strategy using photosensitizers (PSs) and precise wavelength excitation light to introduce reactive oxygen species (ROS) in the vicinity of cancer cells.
Despite the wide range of treatment options available for cancer therapy, including chemotherapy, radiation therapy, and surgical procedures, each of these treatments has a different side-effect profile and leaves the patient with no option but to choose. Due to their insensitivity and nonspecificity, conventional treatments damage normal cells together with cancer cells. In recent years, a significant amount of attention has been focused on photodynamic therapy (PDT) as a treatment for cancer and drug-resistant microbes.
View Article and Find Full Text PDFThe communication network made the globe a single entity and easily acessible by everyone at any time. Growth in communication networks is unimaginable and advanced nowadays. It is growing every day by means of medium or components used in communication.
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- Remediation of hydrocarbon contamination is crucial to protect both land and aquatic environments, with filamentous fungi showing promise for breaking down these pollutants into non-toxic residues.
- The paper outlines three key strategies used by filamentous fungi for hydrocarbon remediation: utilizing hydrocarbons as energy sources, co-metabolism, and biosorption approaches.
- While fungi show great potential for efficient and eco-friendly cleanup methods, more research is needed to understand their interactions with humans and to assess any toxic effects before practical application.