Publications by authors named "P Gorecki"
Characteristics of Patients With Psoriasis Treated With Various Biologics - A Danish Cohort Study.
J Psoriasis Psoriatic Arthritis
April 2024
Article Synopsis
- Psoriasis is often linked with various health issues, including higher rates of obesity, which affects treatment choices and responses for affected individuals.
- This study aimed to examine differences in patient characteristics among those starting or continuing biologic therapies for psoriasis and to assess the use of topical treatments after one year of therapy.
- Findings revealed that younger patients with fewer instances of psoriatic arthritis were treated with ustekinumab, while most other patient factors remained consistent across different biologic treatments, indicating a need for more tailored treatment approaches.
Mild psoriasis may be burdensome; if symptoms are inadequately controlled, switching therapy may be warranted. In the Phase 3 NAVIGATE trial, patients with moderate-to-severe plaque psoriasis received ustekinumab for 16 weeks. Patients with inadequate response (Investigator's Global Assessment [IGA] ≥ 2) were randomized to switch to guselkumab or continue ustekinumab.
View Article and Find Full Text PDFArticle Synopsis
- - Guselkumab, an interleukin-23p19 subunit inhibitor, has shown significant improvements in clinical outcomes and patient-reported results in patients with moderate-to-severe psoriasis, emphasizing the need for personalized treatment approaches based on these factors.
- - A post hoc analysis of the VOYAGE 1 trial revealed that 22.2% of patients maintained complete skin clearance for over three years, with this group showing lower baseline rates of obesity and depression, and a higher rate of non-smokers compared to those who did not maintain clearance.
- - Despite achieving full skin clearance, some patients still reported quality-of-life impacts, particularly in the areas of symptoms and feelings, indicating that clinical measures alone may not fully capture the
Article Synopsis
- - The study explores horizontal gene transfer (HGT) in early diverging fungi (EDF), revealing that these genes enhance metabolic capabilities and adaptation strategies, similar to findings in more studied groups like Dikarya.
- - A computational pipeline was developed to analyze 44 EDF proteomes, identifying 829 foreign genes (xenologs) and uncovering unique patterns of gene exchange, including bursts of transfer and varying molecular properties across fungal lineages.
- - The research highlights that water-dwelling fungi more often acquire foreign genes compared to land fungi, and emphasizes the need for specialized methods to identify HGT events, ultimately providing insights into how HGT impacts fungal evolution and functions.
Introduction And Objective: Escherichia coli is one of the most common bacteria isolated from urine samples collected from dogs and cats with urinary tract infection (UTI). Uncomplicated UTIs in dogs and cats can be treated with short courses of first-line antimicrobial drugs, e.g.
View Article and Find Full Text PDF