Publications by authors named "P Goodfellow"
Mismatch repair (MMR) deficiency can be indicative of Lynch syndrome (LS) and guide treatment with immune checkpoint inhibitors. Colorectal cancers (CRCs) and endometrial cancers (ECs) are routinely screened to identify LS, primarily using immunohistochemistry (IHC) or microsatellite instability (MSI) testing, but concordance between these methods is variable in ECs. Here, we investigate this variability in 361 ECs from the Ohio OCCPI/OPTEC ( = 196) and Manchester PETALS ( = 165) trials, where concordance between assays differed significantly.
View Article and Find Full Text PDFBackground: Mismatch-repair (MMR)/microsatellite instability (MSI) status has therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance of testing and factors contributing to MMR expression heterogeneity.
Methods: Six hundred sixty-six ECs were characterized using immunohistochemistry (IHC), MSI testing, and mut-L homolog 1 (MLH1) methylation.
Article Synopsis
- The study evaluates how mismatch repair (MMR) status affects risk predictions for lymph node involvement and recurrence in endometrioid endometrial cancer patients.
- Around 1,514 cases were analyzed, revealing that 25.9% had MMR deficiencies, predominantly linked to epigenetic changes, which led to higher risk classification for lymphatic spread and recurrence.
- The findings indicate that epigenetic MMR defects are critical prognostic factors, independently associated with a worse disease-free survival, although they do not significantly affect overall survival rates.
Objective: To examine patients with confirmed endometrial cancer recurrence; evaluate patterns, presentation, and mode of diagnosis.
Study Design: A retrospective review of women with endometrial cancer diagnosis between 2014 and 2020. Disease recurrences were evaluated.