Publications by authors named "P Gonzales"

There is increasing evidence that establishes a connection between fluctuations in glucose metabolism and the onset of Alzheimer's disease (AD). Current research supports the notion that this metabolic imbalance significantly affects cognitive health. However, the specific mechanisms through which these fluctuations influence neurodegeneration, eventually leading to AD, require further exploration.

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Article Synopsis
  • Recent treatment options for advanced classical Hodgkin lymphoma have evolved from the longstanding ABVD regimen, with new combinations showing improved survival rates but also increased side effects.
  • A study tested a new treatment protocol (AN+AD) which replaces vinblastine with nivolumab, enrolling patients with treatment-naive stage II bulky or III/IV cHL, leading to promising response rates.
  • At the time of analysis, patients showed an 88% complete response rate and a favorable safety profile, suggesting further investigation into this new combination therapy is necessary.
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Unlabelled: It is estimated that 45% of individuals with cognitive impairment experience sleep disturbances prior to the onset of cognitive symptoms. Assessing sleeping problems and enhancing sleep quality are critical first steps to reduce the risk of cognitive impairment.

Objective: To review existing literature based on predefined eligibility criteria to understand the connection between sleep disturbance and Alzheimer's disease.

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Patient complications and adverse outcomes are inherent to surgical practice and training. In addition to the impact on patients, there are profound and well-documented impacts of complications on surgeons, surgical trainees, and surgical teams. This manuscript reviews the literature regarding mindfulness-based practices and the associated mitigation of the adverse impact of complications.

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