Publications by authors named "P Gomez-Porro"
Article Synopsis
- The study aimed to assess the effectiveness and tolerability of fenfluramine (FFA) in treating Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) in real-world clinical settings from 2018 to 2022.
- Among the 56 patients analyzed, 58% achieved a significant reduction in seizures, with 10% experiencing complete seizure freedom, while notable cognitive and social improvements were observed in a majority of patients.
- Almost 60% of patients reported adverse events related to FFA, mostly mild and self-resolving, with a rare serious event noted that was not directly linked to the treatment.
Background: Ischaemic stroke may be a major complication of SARS-CoV-2 infection. Studying and characterising the different aetiological subtypes, clinical characteristics, and functional outcomes may be valuable in guiding patient selection for optimal management and treatment.
Methods: Data were collected retrospectively on consecutive patients with COVID-19 who developed acute focal brain ischaemia (between 1 March and 19 April 2020) at a tertiary university hospital in Madrid (Spain).
Background: Embolic cerebrovascular events that remain of unknown etiology after a thorough diagnostic evaluation, are known as Embolic Strokes of Undetermined Source (ESUS). Subclinical atrial fibrillation (AF) represents a significant underlying cause of ESUS. Our aims were to examine the overall diagnostic yield of a prolonged cardiac monitoring wearable system (PCMw) after an ESUS to detect AF and factors associated with it, including the time frame from the ESUS event to PCMw initiation.
View Article and Find Full Text PDFSCN8A-developmental and epileptic encephalopathy is caused by pathogenic variants in the SCN8A gene encoding the Na 1.6 sodium channel, and is characterized by intractable multivariate seizures and developmental regression. Fenfluramine is a repurposed drug with proven antiseizure efficacy in Dravet syndrome and Lennox-Gastaut syndrome.
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