Buprenorphine-naloxone versus buprenorphine for opioid use disorder during pregnancy: A systematic review and meta-analysis.

Background: The standard of care for treating opioid use disorder (OUD) during pregnancy includes either buprenorphine or methadone. Although buprenorphine-naloxone presents an alternative due to the reduced risk of misuse , evidence regarding its impact on pregnancy and infant health remains limited. This systematic review and meta-analysis aims to compare buprenorphine-naloxone vs buprenorphine alone for OUD during pregnancy, assessing gestational and neonatal outcomes.

Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.

Breathing regulation depends on a highly intricate and precise network within the brainstem, requiring the identification of all neuronal elements in the brainstem respiratory circuits and a comprehensive understanding of their organization into distinct functional compartments. These compartments play a pivotal role by providing essential input to three main targets: cranial motoneurons that regulate airway control, spinal motoneurons that activate the inspiratory and expiratory muscles, and higher brain structures that influence breathing behavior and integrate it with other physiological and behavioral processes. This review offers a comprehensive examination of the phenotypes, connections, and functional roles of the major compartments within the brainstem and forebrain respiratory circuits.

A novel trypsin inhibitor with immunomodulatory activity from the leaves of Cissus verticillata subsp. verticillata (L.) Nicolson & C.E.Jarvis.

In this study, we purified and characterized a trypsin inhibitor (CvLTI) from the leaves of Cissus verticillata subsp. verticillata. CvLTI was isolated using a trypsin-agarose column and evaluated for stability towards heating (30 to 100 °C) and incubation at different pH values (2.

Galectin-3 organizes histological compartments associated with inflammatory reaction induced by gliadin in BALB/c mice.

Galectin-3 regulates cell-cell and cell-extracellular matrix interactions in distinct tissues, including intestinal epithelial cells interfering with inflammatory responses. In the gut, galectin-3 stabilizes epithelial junctions and intestinal permeability. Here, it was investigated whether gliadin (protein of gluten) can induce inflammatory reactions in the digestive system in the presence or absence of galectin-3.