Relationship between hyperinsulinemia and angiographically defined coronary atherosclerosis in non-diabetic men.

Background: Our aim was to estimate the relationship between hyperinsulinemia and angiographically validated coronary atherosclerosis.

Methods: 102 consecutive non-diabetic male subjects (age 48.9 +/- 9.

Relation between insulinaemia and lipoprotein composition in men with primary arterial hypertension with and without hypertriglyceridaemia.

The purpose of the study was to evaluate a relationship between HDL, triglyceride levels and insulinaemia in primary arterial hypertension. The study population consisted of 60 men aged 32-68 years (mean age 50.87 years, s.

Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH).

L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH). Significant decrease (p < 0.02) of systolic blood pressure (SBP) was observed only during the first day of the therapy and tachyphylaxis against L-Arg was noticed.

Influence of SIN-1 and sodium nitroprusside (NANP) on ox-LDL metabolism in macrophages.

Effects of NO-donors (3-morpholinosydnonimine-SIN-1 and sodium nitroprusside NaNP) on the accumulation and degradation of oxidized LDL (ox-LDL) by macrophages were studied. Ox-LDL, but not native-LDL (n-LDL) suppressed the LPS-stimulated biosynthesis of NO by macrophages. SIN-1 at low concentrations < 100 microM was without any effect while SIN-1 at high concentration (300 microM) and NaNP (30-300 microM) stimulated the accumulation and degradation of ox-LDL by macrophages.