A Prospective, Noninterventional Study to Evaluate the Impact of Emicizumab in the Management of Hemophilia A.

Background and objective Hemophilia A (HA) is a genetic bleeding disorder caused by a lack of factor VIII (FVIII) and is associated with frequent bleeding and joint damage. Traditional intravenous treatments for this condition are cumbersome and can lead to complications. Emicizumab, a bispecific monoclonal antibody, offers a promising subcutaneous alternative with potential safety and efficacy-related benefits.

A Retrospective Analysis of Demographics, Clinical Features, and Treatment Patterns in Sickle Cell Disease Patients at a Tertiary Healthcare Centre of North East India.

Background Sickle cell disease (SCD) is a hereditary disorder marked by abnormal hemoglobin (HbS), leading to chronic hemolytic anemia, vaso-occlusive crises (VOCs), and multi-organ complications. In India, the prevalence of SCD is highest among tribal populations in states like Madhya Pradesh, Maharashtra, Odisha, and Assam, with the disease burden exacerbated by limited healthcare access, especially in rural regions. This study provides a comprehensive analysis of the demographic profile, clinical features, and treatment patterns of SCD patients at a tertiary healthcare center in Upper Assam, where the prevalence of SCD is high among the tea tribe communities.

Phytochemical Characterization, Prooxidant, Antiproliferative And Anti-inflammatory Potential of Meyna spinosa Roxb. ex Link Ripe Fruit.

This study highlights the prooxidant, antiproliferative and anti-inflammatory potential of ripe Meyna spinosa Roxb. ex Link fruit extracts. Chemical analysis by HRMS and AAS identified compounds like ursolic acid, oleanolic acid, lupeol, betulin, scopoletin, phloroglucinol, secoxyloganin, etc and micro-elements like iron, copper, zinc, and manganese.

Enhancement of Sm Luminescence in Sol-Gel Silica Matrix: Effect of Ligands Phenyl Phosphinic Acid and Trioctylphosphine Oxide.

Sol-gel silica matrices singly doped with Sm and co-doped with ligands phenyl phosphinic acid (PPIA) and trioctylphosphine oxide (TOPO) were fabricated and studied for their structural and spectroscopic behaviour. Structural studies were done by x-ray diffraction (XRD) and Fourier transform infra-red (FTIR) absorption analysis whereas spectroscopic behaviour was studied by ultraviolet - visible (UV-Vis) absorption, photoluminescence (PL) excitation, emission and time-correlated decay analyses. XRD studies exhibit the amorphous nature of the samples and FTIR studies corroborate the presence of the ligands in the silica matrix.

Salinity variations drive the phytoplankton dynamics in the Gangetic estuary: insights from the modelling approach for species responses and pollution indicators along the longitudinal estuarine gradient.

Spatial and temporal variation in phytoplankton assemblage and their species responses with varying salinity regimes were investigated in the Hooghly Matlah estuary, India during two annual period. The exhaustive survey in the ten sampling stations recorded 132 species of phytoplankton belonging to 95 genera. The study revealed 12 taxonomic algal groups with the dominance of class Bacillariophyceae (43 species).