Publications by authors named "P Gocke"
Objective: Standardised quantitative analysis of the humoral immune response to SARS-CoV-2 antigens may be useful for estimating the extent and duration of immunity. The aim was to develop enzyme-linked immunosorbent assays (ELISAs) for the quantification of human IgG antibodies against SARS-CoV-2 antigens.
Methods: Enzyme-linked immunosorbent assays were developed based on monoclonal antibodies against human IgG and recombinant SARS-CoV-2 antigens (Spike-S1 and Nucleocapsid).
Article Synopsis
- The COVID-19 pandemic has led to an explosion in app development, but many of these apps lack interoperable data capabilities.
- The COMPASS project from the German COVID-19 Research Network aims to address this issue by providing open-source technology and best practices for creating compatible health applications.
- The project includes a framework for automated conformity checks and reference implementations to support efficient, pandemic-specific app development and encourages developers to adopt interoperable standards.
Article Synopsis
- The study analyzed acute kidney injury (AKI) episodes in over 103,000 hospitalized patients in Germany from 2014 to 2017, using serum creatinine measurements following KDIGO criteria.
- Among 185,760 hospitalizations, significant rates of AKI were found, with increasing in-hospital mortality linked to higher stages of AKI: 5.1% for stage 1, 13.7% for stage 2, and 24.8% for stage 3.
- Administrative coding for AKI was present in only 28.8% of identified cases, indicating a gap in documentation and potential oversight by healthcare providers regarding this serious condition.
Article Synopsis
- The project developed a digital system to collect patient-reported outcome (PRO) data for breast cancer patients at Charité Breast Center, aiming to standardize and compare treatment outcomes.
- In November 2016, a web-based platform using the ICHOM dataset was implemented, enrolling patients who completed questionnaires on tablets and via automated emails during treatment.
- The study enrolled 541 patients, achieving a 67% questionnaire return rate, indicating successful PRO measurement across all age groups, with a small preference for paper versions among older patients.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons of the substantia nigra pars compacta. 6-Hydroxydopamine (6-OHDA) is specific to dopaminergic neurons in intrastriatal rodent models. It induces neuronal death either via uncoupling mitochondrial oxidative phosphorylation resulting in energy deprivation or alternatively, is associated with its ability to produce hydrogen peroxide, hydroxyl and superoxide radicals.
View Article and Find Full Text PDF