Unsuspected lower extremity deep venous thrombosis simulating musculoskeletal pathology.

Objective: The purpose of this study was to highlight the critical role that MRI may play in diagnosing unsuspected lower extremity deep venous thrombosis and to stress the importance of scrutinizing MRI studies of the lower extremity showing apparently non-specific muscle edema for any evidence of intramuscular venous thrombosis.

Design And Patients: The imaging studies of four patients in whom deep venous thrombosis was unsuspected on clinical grounds, and first diagnosed on the basis of MRI findings, were reviewed by two musculoskeletal radiologists in consensus. In all four patients the initial clinical suspicion was within the scope of musculoskeletal injuries (gastrocnemius strain, n=3; ruptured Baker cyst, n=1), explaining the choice of MRI over ultrasound as the first diagnostic modality.

Flexor carpi radialis tendinopathy: spectrum of imaging findings and association with triscaphe arthritis.

Objective: To present the spectrum of pathology affecting the flexor carpi radialis (FCR), and its anatomical, functional and clinical relationship with conditions affecting the triscaphe or scapho-trapezium-trapezoid (STT) compartment, and particularly osteoarthritis.

Design: The study comprised two men and four women aged between 23 and 79 years (mean age, 49 years). Two musculoskeletal radiologists in consensus evaluated MRI findings.

Insulin sensitivity of splanchnic and peripheral adipose tissue in vivo in morbidly obese man.

Epidemiologic studies demonstrate an association between increased waist to hip ratio ([WHR] android obesity, central obesity) and diabetes mellitus in man. To study the relative insulin sensitivity of splanchnic versus peripheral adipose tissue, portal vein catheterization via the collapsed umbilical vein was performed in 14 morbidly obese subjects at the time of surgery. Catheters were also placed in a peripheral artery and antecubital vein such that simultaneous arterio-venous (A-V) differences (glycerol, free fatty acids [FFA], and lactate) could be determined.

In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans.

To examine the effect of increased gluconeogenesis [by increasing free fatty acids (FFA)] on hepatic glucose output (HGO) and on the first substrate (glucose) cycle, a primed continuous infusion of [2-3H]- and [6-14C]glucose was infused to isotopic steady state in 12 normal male volunteers after an overnight fast. Blood samples for the determination of glucose specific activity were obtained before and after an infusion of saline (n = 6) or 10% Intralipid and heparin (90 mU.kg-1.

Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men.

We previously reported a fall in hepatic glucose output (HGO) during sleep accompanied by reductions in glucose utilization (Rd) and free fatty acids (FFAs). This study was undertaken to determine the potential role of changes in Rd and FFA on HGO in nondiabetic men. To determine if the fall in HGO during sleep could be reversed by FFA elevation, seven nondiabetic men underwent [3-3H]glucose infusions from 2200 to 0800, with heparin (90 mU.