Publications by authors named "P Gionchetti"
Background: Nowadays, there is a clear need for new viable therapeutic options to face complex perianal Crohn's disease (PCD). Results of our previous pilot study demonstrated the efficacy and safety of local injection of autologous microfragmented adipose tissue (MFat) in this setting. This study aims to evaluate the long-term follow-up results in the same cohort of patients.
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- Cytomegalovirus (CMV) colitis significantly worsens the prognosis for patients suffering from moderate-to-severe ulcerative colitis (UC), with a study identifying several risk factors related to its occurrence.
- In a study of 135 hospitalized patients, CMV colitis was diagnosed in approximately 27.4% of cases, and those with CMV colitis had a higher age and comorbidity index, along with increased rates of steroid refractoriness and CMV-DNAemia.
- Patients with CMV colitis were more likely to require colectomy within 30 days, highlighting the importance of early diagnosis and potential benefits of antiviral treatment, with the need for further research suggested to clarify CMV-DNA
Background & Aims: Vedolizumab is indicated for the treatment of chronic pouchitis in the European Union. We assessed whether vedolizumab induced mucosal healing (MH) and if MH was associated with clinical improvements.
Methods: EARNEST, a randomized, double-blind, placebo-controlled study, evaluated vedolizumab efficacy and safety in adults with chronic pouchitis.
Article Synopsis
- The study investigates postoperative complications following ileocaecal resection in patients with Crohn's Disease, specifically focusing on intra-abdominal septic complications (IASCs) and severe POCs.
- Analysis of 853 patients revealed significant rates of complications, with lower preoperative albumin levels and a history of cardiovascular diseases being key predictors of severe POCs.
- The findings suggest that oral budesonide is linked to a higher risk of IASCs, indicating the need for careful evaluation of this medication before surgery.