Publications by authors named "P Ginod"
Article Synopsis
- A retrospective cohort study was conducted to compare population characteristics and obstetric complications between abdominal and laparoscopic myomectomy using data from over 20% of U.S. hospital admissions from 2004 to 2014.
- The study included 13,868 pregnancies after abdominal myomectomy and 338 after laparoscopic myomectomy, analyzing the impact on pregnancy, delivery, and neonatal outcomes.
- Results indicated that laparoscopic myomectomy was associated with lower rates of several complications, such as pregnancy-induced hypertension and preterm delivery, compared to abdominal myomectomy, while also involving younger patients with fewer adverse health factors.
The recent commercialization of the Embryo Health Score (EHS), determined through preimplantation genetic testing for polygenic conditions, offers the potential to select embryos with lower disease risk, thus potentially enhancing offspring longevity and health. Lately, Orchid Health company increased testing from less than 20 diseases to more than 900+ conditions for birth defects. However, the "geneticization" of phenotype estimates to a health state erases the environmental part, including the in vitro fertilization potential risks, questioning its scientific usefulness.
View Article and Find Full Text PDFPolygenic embryo screening: are there potential maternal and fetal harms?
Reprod Biomed Online
December 2023
Polygenic embryo screening (PES) and its derivate the Embryo Health Score (EHS) have generated interest in both infertile and fertile populations due to their potential ability to select embryos with a reduced risk of disease and improved long-term health outcomes. Concerns have been raised regarding the potential harms of IVF itself, including possible epigenetic changes that may affect the health of the offspring in late adulthood, which are not fully captured in the EHS calculation. Knowledge of the potential impacts of the trophectoderm biopsy, which is a key component of the PES procedure, on the offsprings' health is limited by the heterogeneity of the population characteristics used in the published studies.
View Article and Find Full Text PDFArticle Synopsis
- The research investigates how the timing of conception—natural vs. intrauterine insemination (IUI)—affects the epigenetic control of certain genes at birth, specifically imprinted genes and transposable elements.
- Four groups of pregnancies were studied based on the length of infertility and conception methods, revealing differences in DNA methylation levels and gene expression across these groups.
- Findings suggest that infertility itself may pose epigenetic risks to offspring, indicating potential long-term implications beyond just assisted reproductive technologies (ART).