Publications by authors named "P Giner"
Nicotine use is driven by pleasurable effects, but following chronic exposure, nicotine use becomes largely driven by the desire need to avoid withdrawal symptoms. Current cessation strategies focusing on alleviating withdrawal, but current cessation interventions are less effective for women than men. Also, hormone fluctuations across the menstrual cycle appear to impact use patterns, withdrawal severity, and treatment efficacy.
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- A study was conducted on male and female rats to investigate how diabetes medications interact with nicotine consumption after being placed on a high-fat diet (HFD) or regular diet (RD) for 4 weeks, followed by insulin resistance testing.
- The rats that were on the high-fat diet displayed higher nicotine intake compared to those on the regular diet, and both female and male rats showed similar insulin resistance after receiving a low dose of the diabetes medication streptozotocin (STZ).
- The findings indicated that insulin administration normalized nicotine intake in HFD-fed rats, suggesting that insulin may effectively manage excessive nicotine consumption in individuals with diabetes.
Article Synopsis
- - The lab focuses on understanding why certain groups, especially vulnerable populations, are more likely to use nicotine, using a study that exposed rats to nicotine vapor for 14 days.
- - The study examined how age and sex influence behavior towards nicotine, finding that adolescent females were more inclined to seek out nicotine compared to males and adults, and this behavior was linked to increased anxiety.
- - Results showed that adolescent females not only had the highest nicotine levels but also gained more weight than adults, indicating that they may experience stronger motivational effects from nicotine vapor.
While the cognitive enhancing effects of nicotine use have been well documented, it has also been shown to impair decision making. The goal of this study was to determine if exposure to nicotine vapor increases risky decision making. The study also aims to investigate possible long-term effects of nicotine vapor exposure on the expression of genes coding for cholinergic and dopaminergic receptors in brain.
View Article and Find Full Text PDFThe present study assessed the sex-dependent effects of insulin resistance on the reinforcing effects of nicotine. Female and male rats received a chronic high-fat diet (HFD) or regular diet (RD) for 8 weeks. A subset of rats then received vehicle or a dose of streptozotocin (STZ; 25 mg/kg) that induces insulin resistance.
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