Publications by authors named "P Gillberg"
Article Synopsis
- This study investigates the metabolic and bioenergetic changes in the spinal cord of a transgenic mouse model of Parkinson's disease (M83) that overexpresses a mutated form of alpha-synuclein, comparing it to non-transgenic mice.!* -
- Using advanced imaging techniques, the researchers found that the M83 mice had lower oxygen saturation levels in their spinal cords, but there were no significant changes in spinal cord volume or vascular organization despite the presence of phosphorylated alpha-synuclein.!* -
- The study highlights the development of deep learning tools for analyzing spinal cord MRI data, and underscores the complexity of Parkinson's disease by showing reduced oxygen levels without related structural changes in the spinal cord.!
Background And Aims: Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role in BA reabsorption and signaling in ileum, bile ducts, and kidneys. Our aim was to investigate the pharmacokinetics and pharmacological activity of A3907, an oral and systemically available ASBT inhibitor in experimental mouse models of cholestasis.
View Article and Find Full Text PDFRecent mechanistic and structural studies have challenged the classical tauopathy classification approach and revealed the complexity and heterogeneity of tau pathology in Alzheimer's disease (AD) and primary tauopathies such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), progressing beyond distinct tau isoforms. In this multi-tau tracer study, we focused on the new second-generation tau PET tracers PI2620, MK6240 and RO948 to investigate this tau complexity in AD, CBD, and PSP brains using post-mortem radioligand binding studies and autoradiography of large and small frozen brain sections. Saturation binding studies indicated multiple binding sites for H-PI2620 in AD, CBD and PSP brains with different binding affinities (K ranging from 0.
View Article and Find Full Text PDFBackground And Aim: Elobixibat is a locally acting inhibitor of the ileal bile acid transporter. We compared bile acid metabolism between healthy subjects and patients with chronic constipation and assessed changes in the bile acid profile after elobixibat administration in the latter group.
Methods: Healthy subjects (n = 10) and patients with chronic constipation (n = 19) were assessed as inpatients for 7 days, during which they received meals containing ~60 g/day of fat.