Publications by authors named "P Giavedoni"
This retrospective cohort study assessed the efficacy and safety of Janus kinase (JAK) inhibitors, tofacitinib and baricitinib, in 14 patients with refractory dermatomyositis (DM), a multisystemic autoimmune disorder with limited therapeutic options. Results demonstrated a significant median decrease of 21 points and a 76% reduction in the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) scores, along with a complete resolution of muscular symptoms in 64% of the patients. JAK inhibitors were effective in managing refractory DM across various subtypes with mild and manageable adverse events.
View Article and Find Full Text PDFDisease phenotypes in adult patients with suspected undifferentiated autoinflammatory diseases and PFAPA syndrome: Clinical and therapeutic implications.
Autoimmun Rev
September 2024
Article Synopsis
- The study focuses on defining and characterizing the disease phenotypes of adult patients with undifferentiated autoinflammatory diseases who experienced recurrent fevers and inflammatory issues, with inconclusive genetic tests.
- It analyzed 134 patients from a reference center over several years, identifying five phenotypes, including a significant number meeting the criteria for PFAPA syndrome and several with varying predominant symptoms.
- The treatment analysis found that medications like prednisone, colchicine, and anakinra were commonly prescribed, with effectiveness rates of 41.3%, 40.2%, and 58.3% for complete responses, respectively, with specific preferences for medications based on patient phenotype.
Background: The development of skin cancer is closely related to high exposure to UV radiation. Lifeguards are at an increased risk of excessive sun exposure.
Objectives: The main objective of this study was to measure the exposure of Barcelona's beach lifeguards to UV radiation.