Publications by authors named "P Giacomello"

In this work, essential oils (EOs) and hydrolates (Hys) of L. and Mill., grown in Tuscany (Italy), were studied to describe their chemical composition and biological activities.

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Lavandin essential oil (LEO), a natural sterile hybrid obtained by crossbreeding is mainly composed by active components belonging to the family of terpenes endowed with relevant anti-proliferative activity, which can be enhanced by proper application of nanotechnology. In particular, this study reports the chemical characterization and the screening of the anti-proliferative activity on different human cell lines of pure and nano-formulated lavandin essential oil (EO). LEO and its formulation (NanoLEO) were analyzed by HS/GC-MS (Headspace/Gas Chromatography-Mass Spectrometry) to describe and compare their chemical volatile composition.

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Article Synopsis
  • * Leaf extracts were tested against various microbes, and those showing activity were further separated into fractions using low-pressure column chromatography (LPCC) for more detailed analysis.
  • * The active fractions were rich in sesquiterpenes and terpenoids, showcasing significant antimicrobial properties and highlighting the potential of (L.) leaf compounds as bioactive substances for pharmaceutical development.
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Recent scientific investigations have reported a number of essential oils to interfere with intracellular signalling pathways and to induce apoptosis in different cancer cell types. In this paper, Lavandin Essential Oil (LEO), a natural sterile hybrid obtained by cross-breeding  ×  was tested on human leukaemia cells (HL60). Based on the MTT results, the reduced cell viability of HL60 cells was further investigated to determine whether cell death was related to the apoptotic process.

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