Publications by authors named "P Ghazal"
Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for alcohol use disorder in women than men, and binge alcohol drinking is correlated with high estrogen levels, but a causal role for estrogen in driving alcohol drinking has not been established. We found that female mice displayed greater binge alcohol drinking and reduced avoidance when estrogen was high during the estrous cycle than when it was low.
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- The study investigates the relationship between IL-6 signaling, particularly through the SNP rs2228145, and the risk of developing tuberculosis (TB), considering that inhibitors of IL-6 signaling might increase TB progression risk.
- The researchers conducted a meta-analysis of various genome-wide association studies (GWAS) to analyze genetic data and extract effect estimates related to the C allele of rs2228145, which is associated with reduced IL-6 signaling.
- Preliminary findings include data from 17 GWAS, covering a substantial sample of individuals with tuberculosis and a large control population, aiming to understand how genetic factors might influence TB susceptibility.
Background: Sepsis is a common cause of serious illness and death. Sepsis management remains challenging and suboptimal. To support rapid sepsis diagnosis and treatment, screening tools have been embedded into hospital digital systems to appear as digital alerts.
View Article and Find Full Text PDFBackground: Wheezing in childhood is prevalent, with over one-half of all children experiencing at least 1 episode by age 6. The pathophysiology of wheeze, especially why some children develop asthma while others do not, remains unclear.
Objectives: This study addresses the knowledge gap by investigating the transition from preschool wheeze to asthma using multiomic profiling.