Publications by authors named "P Geoghegan"
Article Synopsis
- The study investigates how different diets (high-fat, high-carbohydrate, or a combination) affect the severity of damage caused by Shiga toxin 2 in the brains of mice, focusing on areas related to motor activity.
- Mice fed high-fat and high-carbohydrate diets experienced greater harm from Shiga toxin 2, with the worst outcomes noted in those on a combined diet, including neurodegeneration and impaired motor functions.
- The findings suggest that poor nutrition may worsen neurological damage in patients affected by Shiga toxin, indicating that diet can play a critical role in the severity of toxin-induced effects.
Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons for ECD with one being an induced increase in shear on the corneal wall.
View Article and Find Full Text PDFBackground: Transfer of all severe TBI patients to a neurosurgical unit (NSU) has been advocated irrespective of levels of complexity and prognostic factors. Previous publications have suggested that only 50% of severe TBI patients in Ireland were managed in NSUs.
Aims: This study aims to audit severe TBI referrals to the National Neurosurgical Centre, to evaluate reasons for nonacceptance, assess for differences in the transferred and not transferred cohorts and to analyse observed and expected mortality rates.
Background: There is a lack of consistent, evidence-based guidelines for the management of patients with fever after brain injury. The aim was to update previously published consensus recommendations on targeted temperature management after intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke in patients who require admission to critical care.
Methods: A modified Delphi consensus, the Neuroprotective Therapy Consensus Review (NTCR), included 19 international neuro-intensive care experts with a subspecialty interest in the acute management of intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke.