Publications by authors named "P Genest"

The growing demand for psychiatric care raises questions about the place and value of alternatives to hospitalization. Community-based intensive care, such as home-based intensive care teams, are models that have been extensively studied and precisely described in international literature. They make it possible to avoid or shorten hospital stays, and have interesting variations for providing access to care in rural areas.

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Unlabelled: This article describes a four virus panel validation of EMD Millipore's (Bedford, MA) small virus-retentive filter, Viresolve® Pro, using TrueSpike(TM) viruses for a Biogen Idec process intermediate. The study was performed at Charles River Labs in King of Prussia, PA. Greater than 900 L/m(2) filter throughput was achieved with the approximately 8 g/L monoclonal antibody feed.

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Article Synopsis
  • Base J (β-D-glucosyl-hydroxymethyluracil) is a modified nucleobase in the Leishmania genome, replacing 1% of thymine (T) mainly in telomeric regions and transcription sites.
  • JBP1 and JBP2 are thymidine hydroxylases that initiate the synthesis of Base J, which specifically targets DNA sequences recognized during this process.
  • Research using SMRT sequencing revealed that J modifications typically occur at pairs of Ts on opposite strands and are dependent on JBP2, supporting a model where JBP2 facilitates new J insertions while JBP1 maintains it during DNA replication.
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Background: Advance Directives are written documents, which are used for people to notify their preference for a future situation when they are unable to give their consent. In psychiatry, psychiatric advance directives (PADs) can be used for patients with chronic psychotic disorders such as schizophrenia, or a bipolar disorder. PADs give the patient an opportunity to state wishes in advance about his/her treatment when he/she is in an acute state of illness.

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Schizophrenia is a serious, chronic illness which, when treated early, can result in a better prognosis. The putting in place of treatment is often delayed because it is difficult to identify early schizophrenic disorders. At this stage of the illness, the doctor participates as much as the family and the patients themselves in the delay of the diagnosis.

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