Publications by authors named "P Gaunt"
Introduction: Ewing sarcoma is a rare paediatric cancer. Currently, there is no way of accurately predicting these patients' survival at diagnosis. Disease type (ie, localised disease, lung/pleuropulmonary metastases and other metastases) is used to guide treatment decisions, with metastatic patients generally having worse outcomes than localised disease patients.
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- This study investigates how to make radiotherapy for soft tissue sarcoma of the extremities (STSE) more effective while minimizing long-term side effects like tissue damage and joint stiffness.
- It involves two main parts: a retrospective analysis (PredicT A) to create a model predicting radiation side effects and a prospective study (PredicT B) to test these predictions with 150 patients.
- The research has ethical approval and aims to share results through publications and conferences to inform the medical community and local charities.
Article Synopsis
- About 40% of head and neck cancer patients face recurrence after treatment, prompting a need for modified follow-up strategies beyond current guidelines, which lack strong evidence for effectiveness.
- PETNECK2 is a UK-based study that is testing a new follow-up approach using PET-CT scans and allowing patients to manage their own follow-up based on symptoms.
- The study aims to improve overall survival rates and gather insights on patient experiences and anxiety regarding cancer recurrence through a randomized controlled trial and embedded feasibility study.
Background: Patients with intermediate and high-risk oropharyngeal cancer (OPC) have poorer response to standard treatment and poorer overall survival compared to low-risk OPC. CompARE is designed to test alternative approaches to intensified treatment for these patients to improve survival.
Methods: CompARE is a pragmatic phase III, open-label, multicenter randomised controlled trial with an adaptive multi-arm, multi-stage design and an integrated QuinteT Recruitment Intervention.