Publications by authors named "P Gass"
Synthetic small molecule scavengers that rapidly detoxify nerve agents in vivo allow (pre)treatment of nerve agent poisoning. However, scavengers that detoxify persistent V-type nerve agents at pH 7.4 and 37 °C with sufficient efficiency are still unknown.
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- The study investigates the role of CCND1 gene amplification in the prognosis of hormone receptor-positive breast cancer patients, particularly in the context of resistance to endocrine therapy.
- A cohort of 894 breast cancer patients was analyzed, revealing that 12.9% had CCND1 amplification, predominantly in luminal B-like and HER2-positive tumor types.
- The findings indicate that while CCND1 amplification is common in certain breast cancer subtypes, it does not show significant differences in disease-free survival or overall survival among HR-positive, HER2-negative patients.
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- The study focuses on the diagnostic challenges of colposcopy in women aged 50 and older, particularly those with postmenopausal status and transformation zone type 3 (TZ3), highlighting the role of endocervical curettage (ECC) in diagnosing cervical lesions.
- By analyzing data from colposcopies performed at Erlangen University Hospital between 2016 and 2023, researchers correlated Pap and HPV results with histologic findings from ECC.
- The findings reveal that ECC can effectively detect significant lesions, including high-grade cervical intraepithelial neoplasia (CIN) and invasive carcinoma, even in patients with normal colposcopic results, underscoring its importance in diagnostic procedures.
Background: Prognostication has been used to identify patient populations that could potentially benefit from treatment de-escalation. In patients with hormone receptor-positive (HRpos), human epidermal growth factor receptor 2-negative (HER2neg) early breast cancer (eBC), treatment de-escalation classically involved omitting chemotherapy. With recently developed specialized therapies that require hands-on side-effect management, the therapeutic landscape is changing and therapy decisions are no longer based only on prognosis, but also consider potential side-effects.
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