Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform.

Autologous cell-based therapeutics have gained increasing attention in recent years because of their efficacy at treating diseases with limited therapeutic options. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical success in hematologic oncology indications, providing critically ill patients with a potentially curative therapy. Although engineered cell therapies such as CAR T cells provide new options for patients with unmet needs, the high cost and complexity of manufacturing may hinder clinical and commercial translation.

Extension of the method of moments for population balances involving fractional moments and application to a typical agglomeration problem.

The method of moment (MOM) is a powerful tool for solving population balance. Nevertheless it cannot be used in every circumstance. Sometimes, in fact, it is not possible to write the governing equations in closed form.

[Paraneoplastic pemphigus in chronic lymphocytic leukemia].

Introduction: Paraneoplastic pemphigus is an autoimmune bullous disease described by precise clinical, histological and immunological features presented by Anhalt in 1990. Prognosis is very severe and depends on the associated neoplasia and the gravity of the mucosal damage.

Case Report: Paraneoplastic pemphigus was diagnosed in a 62-year-old man with chronic lymphoid leukemia.

Sequential feeding of whole wheat to growing broiler chickens.

1. Four broiler feeding trials were performed to examine the suitability of a whole wheat sequential feeding regimen for commercial broiler production. The sequential feeding programme gave a continuous cycle of ad libitum access to only whole wheat followed by the same time of access to only a pelleted diet.

[A new case of Caffey's disease].

With reference to a new case of Caffey's disease, or infantile cortical hyperostosis, of maxillary origin, the authors stress in particular the necessity to eliminate the possibility of Silverman's syndrome and the diagnostic problem posed by chronic tumefactions of the angle in children.