Publications by authors named "P Garcia-Gutierrez"
Article Synopsis
- - The study focuses on the TATA-binding protein (TBP) gene in *Taenia solium*, revealing the presence of transcription factor binding sites and two TATA-like elements in its promoter, which do not bind TBP.
- - Researchers identified key elements important for gene expression, such as the transcription start site and a downstream promoter element (DPE), and confirmed the expression of TBP-Associated Factors TsTAF6 and TsTAF9 in the parasite.
- - Molecular dynamics simulations provided insights into how TsTAF6 and TsTAF9 interact with the DPE probe, leading to a proposed interaction model that underscores their novel role in regulating transcription in *T. solium*.
Article Synopsis
- Taenia solium can lead to serious health issues like taeniasis and cysticercosis, particularly neurocysticercosis, which is a focus for disease control and mental health prevention.
- Structural analysis of the 24-kDa glutathione transferase gene (Ts24gst) revealed its conserved architecture and potential regulatory elements, indicating its importance in the parasite's survival.
- The recombinant Ts24GST protein demonstrated strong biochemical activity and stability under various conditions, enhancing our understanding of T. solium and aiding efforts to combat related diseases.