Publications by authors named "P Garas"
Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited.
Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study.
Article Synopsis
- The study aimed to investigate the long-term safety of methylphenidate (MPH), particularly regarding its impact on pubertal maturation and bone age.
- Participants from a two-year observational study were compared across three groups: those on MPH, those not on MPH, and a control group without ADHD.
- Results showed no differences in sexual maturation between medicated and unmedicated ADHD groups, and while there was slight bone maturation acceleration in the medicated group, their predicted adult height remained stable, indicating no long-term safety concerns with MPH.
Background: Methylphenidate is the most frequently prescribed medication for the treatment of ADHD in children and adolescents in many countries. Although many randomised controlled trials support short-term efficacy, tolerability, and safety, data on long-term safety and tolerability are scarce. The aim of this study was to investigate the safety of methylphenidate over a 2-year period in relation to growth and development, psychiatric health, neurological health, and cardiovascular function in children and adolescents.
View Article and Find Full Text PDFPurpose: Adolescents have to cope with several challenges and restrictions due to the COVID-19 pandemic, with many of those incongruent with the typical developmental tasks of adolescent age. Some adolescents might be particularly vulnerable in this situation, including those who are deprived of psychological, social or health care services and/or are exposed to abuse or neglect in their home environment. The aims of the current international multicentre follow-up study are to: 1.
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