Publications by authors named "P Galvan-Blasco"
Article Synopsis
- Hereditary angioedema (HAE) is a rare disorder that causes localized swelling due to an increase in bradykinin, but the impact of inflammation during attacks hasn't been well-studied.
- Researchers analyzed blood samples from 78 HAE patients during both symptom-free periods and active attack phases, measuring inflammatory markers like serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), and D-Dimer.
- Findings showed that during attacks, 88% of patients had elevated SAA, 65% had increased ESR, and 71% showed higher D-Dimer levels, suggesting a significant inflammatory response during HAE attacks compared to baseline levels.
Cystic fibrosis transmembrane conductance regulator modulators are the only available treatment for cystic fibrosis. Although elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is well-tolerated, rash has been reported as very frequent. In severe rashes, ELX/TEZ/IVA withdrawal is necessary, leading to clinical deterioration.
View Article and Find Full Text PDFBackground: Drug provocation tests (DPT) are considered the gold standard procedure to ascertain the diagnosis of beta-lactam (BL) allergy. Regarding route of administration, current recommendations prioritize oral challenges, considering them safer, and reserving the intravenous route for drugs for which this is the only formulation.
Objective: To compare in terms of tolerance and safety two protocols of BL DPT, using an oral protocol (OR-DPT) and an intravenous protocol (IV-DPT).
Purpose Of Review: The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes.
Recent Findings: New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines.
Summary: Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction.