Publications by authors named "P Galuppo"
Introduction: Tissue Fibroblast Activation Protein alpha (FAP) is overexpressed in various types of acute and chronic cardiovascular disease. A soluble form of FAP has been detected in human plasma, and low circulating FAP concentrations are associated with increased risk of death in patients with acute coronary syndrome. However, little is known about the regulation and release of FAP from fibroblasts, and whether circulating FAP concentration is associated with tissue FAP expression.
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- Inflammaging is a pro-inflammatory state associated with aging that heavily involves macrophages, playing a significant role in age-related diseases.
- Macrophage-specific deficiency of mineralocorticoid receptors (MR) prevents the differentiation of macrophages into a pro-inflammatory state, which is crucial in modulating inflammation and fibrosis in the aging heart.
- The study indicates that MR deficiency in macrophages reduces inflammation and fibrosis in the aging heart, suggesting that targeting the MR could be a potential strategy for treating age-related cardiac issues.
Article Synopsis
- Alveolar hypoxia may help protect the heart from failure caused by left ventricular pressure overload (LVPO), although the specific mechanisms behind this protection are not fully understood.
- A new mouse model (HxTAC) was created that combines chronic hypoxia with LVPO, showing resistance to heart failure and identifying key protective mechanisms such as enhanced angiogenesis and preserved metabolic function.
- Findings suggest that hypoxia reduces the impact of LVPO-induced heart failure and may also play a role in recovery after heart failure treatments like left ventricular assist devices, highlighting its potential as a therapeutic target.
Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity.
Am J Physiol Heart Circ Physiol
December 2022
Article Synopsis
- * Researchers tested whether a lack of vitamin A accelerates cardiomyopathy in mice with diet-induced obesity by subjecting them to a high-fat diet devoid of vitamin A, while control mice received a nutrient-sufficient diet.
- * Findings revealed that while cardiac function and mitochondrial respiration were largely maintained despite vitamin A deficiency, the expression of key genes related to cardiac energy metabolism was significantly dependent on vitamin A, indicating its crucial role in preserving cardiac health in obesity.
Insulin and insulin-like growth factor 1 (IGF1) signaling is transduced by insulin receptor substrate 1 (IRS1) and IRS2. To elucidate physiological and redundant roles of insulin and IGF1 signaling in adult hearts, we generated mice with inducible cardiomyocyte-specific deletion of insulin and IGF1 receptors or IRS1 and IRS2. Both models developed dilated cardiomyopathy, and most mice died by 8 weeks post-gene deletion.
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