Publications by authors named "P Gajewski"
Background: Exhaustion and depersonalization are the core symptoms of the occupational burnout. However, burnout is not an all-or-nothing phenomenon, but can occur in a milder to moderate form in otherwise healthy employees. In the last two decades hair cortisol concentrations (HCC) were increasingly related to the cumulative effect of psychosocial stress at work.
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- Heart failure (HF) is a serious condition where the heart fails to pump enough blood, leading to poor organ function and fluid accumulation.
- Recent research highlights the role of microRNAs (miRNAs) in regulating gene expression related to HF, implicating specific miRNAs like miR-30d and miR-126-3p in heart function and remodeling.
- Understanding both traditional biomarkers (like natriuretic peptides and troponins) and newer diagnostic methods can enhance the management of HF and its impact on other organs like the kidneys and liver.
Background: The aim of the study was to analyze the potential relationship between the diuretic response, the clinical profile and the concentrations of selected biochemical markers and to identify a group of patients who will benefit from a new form of therapy combining standard diuretic therapy with the use of a RenalGuard® system.
Methods: This is a retrospective study of 19 patients (mean age 67 ± 10 years, 95% men) hospitalized due to acute decompensated heart failure (ADHF, NYHA class III-IV, BP 125 ± 14/73 ± 16 mmHg, eGFR 58 ± 24) with persistent overhydration despite standard therapy. A targeted comparative analysis of selected clinical and biochemical parameters was performed to determine the parameters associated with a better diuretic response [good diuretic responders (GDR) group].