Local and global dynamics of a prey-predator system with fear, Allee effect, and variable attack rate.

Fear prompts prey to adopt risk-averse behaviors, such as reduced foraging activity, increased vigilance, and avoidance of areas with high predator presence, which affects its reproduction. In a real scenario, a population requires a minimum density to avoid extinction, known as an Allee threshold. In light of these biological factors, we propose a predator-prey model with (i) a fear effect in a prey population, (ii) an Allee effect in a predator population, and (iii) a non-constant attack rate that modifies the functional response.

Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.

Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberculosis through inhibition of ATPase activity catalyzed by the GyrB domain of DNA gyrase. A homology model of the M.

Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B.

A pharmacophore-based search led to the identification of thiazolopyridine ureas as a novel scaffold with antitubercular activity acting through inhibition of DNA Gyrase B (GyrB) ATPase. Evaluation of the binding mode of thiazolopyridines in a Mycobacterium tuberculosis (Mtb) GyrB homology model prompted exploration of the side chains at the thiazolopyridine ring C-5 position to access the ribose/solvent pocket. Potent compounds with GyrB IC50 ≤ 1 nM and Mtb MIC ≤ 0.

Effect of organic versus inorganic fluoride on enamel microhardness: An in vitro study.

Introduction: Dental caries is one of the most prevalent infectious diseases affecting the human dentition. Fluorides are effective anti-carious agents and have been widely used for caries prevention in the form of systemic and topical fluorides. Neutral sodium fluoride (NaF) is commonly used as a topical fluoride agent.

Readability and Missing Data Rates in CAHPS 2.0 Medicare Survey in African American and White Medicare Respondents.

PURPOSE: Examine associations between readability of survey items and missing data rates in a sample of White and African American (AA) Medicare enrollees in managed care plans. METHODS: Consumer Assessment of Healthcare Provider and Systems (CAHPS(®)) 2.0 health plan survey data collected from 139,284 respondents (127,524, Whites and 11,760, AAs) in 321 health plans.