[Efficacy of using VEGF165 gene in comprehensive treatment of patients with stage 2A-3 lower limb chronic ischaemia].

The authors share their experience in treating a total of 100 patients presenting with stage 2A-3 chronic lower limb ischaemia according to the classification of Pokrovsky-Fontain (the clinical group was composed of 75 patients and the control group comprised 25 subjects), in whom it was impossible to perform surgical revascularization. The clinical group patients received in addition to the conventional vascular therapy local intramuscular injections of Neovasculogen (plasmid genetic construction containing human gene VEGF165) at a course dose of 2.4 mg.

[A lobular version of pathogenesis of vascular-aetiology trophic ulcers].

Presented in the article is an original version of the development of vascular-genesis trophic ulcers. The authors have for the first time come out with a suggestion on the relationship between the lobular structure of tissues and microcirculation. To describe this relationship they introduce the notion of the haemodynamic module (HM).

[Uninterruptedly relapsing pulmonary artery thromboembolism as a distinct nosological entity].

It is known that the clinical course of thromboembolism may consist of several episodes, the "light" intervals between which may fluctuate from several hours to several days. Owing to these intervals, surgical prevention of recurrent thromboembolisms became possible and available. Based on long-term follow up of clinical patterns of the diseases, we suppose that it is possible to single out yet another special type of the disease's course which we termed uninterruptedly relapsing pulmonary artery thromboembolism.

[Antioxidant activity and functional endothelium characteristics before and after the operation in patients with atherosclerosis obliterans].

Data of 410 male patients operated on account of atherosclerosis obliterans of lower limbs vessels. Biochemichal parameters of functional endothelium status of the arteriae after operative treatment are studied. Superoxide dismutase activity and nitric oxide level are registered before and 5 days after the operation.

[Hyperplasia of the intima as a cause of restenosis following reconstructive and endovascular operations on lower limb arteries].

The authors herein analyse the role of intimal hyperplasia in the development of restenosis as a late complication in reconstructive surgery of arteries in patients suffering from atherosclerosis obliterans of the arteries of the lower extremities.