Publications by authors named "P G Scheffer"

From an ethical point of view, there is an important distinction between two types of prenatal screening. The first of these targets maternal or foetal conditions (e.g.

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Article Synopsis
  • Early risk assessment in pregnancy can help prevent serious issues like preeclampsia and gestational diabetes by identifying at-risk mothers early on.
  • This study reviewed 77 articles on first-trimester prediction models focused on maternal characteristics, excluding those using biochemical or ultrasound data, and found varied effectiveness in predicting outcomes.
  • Many of the models showed a high risk of bias, and there’s a need for better validation processes, indicating that while tools exist, their reliability and clinical use must be improved.
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Objective: To assess the added value of fetal fraction of cell-free DNA in the maternal circulation in the prediction of adverse pregnancy outcomes.

Design: Retrospective cohort study.

Setting: Nationwide implementation study on non-invasive prenatal testing (NIPT; TRIDENT-2 study).

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Objective: To explore the perspectives of pregnant women on broadening the scope of noninvasive prenatal testing (NIPT) from screening for foetal aneuploidies to prediction of adverse pregnancy outcomes.

Methods: Four online focus groups (n = 23 participants) and 14 individual semi-structured interviews were conducted. Participants included pregnant women with and without a history of adverse pregnancy outcomes.

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