Publications by authors named "P G Sacks"
Background: Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL-4, -5, and -13 are prominent disease mediators. Disease control can be achieved with biologic therapies.
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- Radiomics involves extracting features from medical imaging data to enhance clinical applications, especially in rhinology where CT imaging of the paranasal sinus is crucial for diagnosis and treatment assessment.
- A systematic review analyzed techniques for radiomic data derived from CT scans, resulting in 10 eligible studies categorized into diagnostics and prognostics, using various extraction methods and analytical approaches.
- While the potential of radiomics in rhinology is promising, the current studies show variable quality and limited clinical applicability, indicating a need for more robust research in this area.
Objective: To assess the effect of allergen immunotherapy (AIT) on patients with central compartment atopic disease (CCAD) and house dust mite (HDM) sensitization post-surgery.
Methods: A retrospective cohort of surgically treated, HDM-sensitized CRSwNP patients phenotyped as CCAD was assessed. Patients were divided into two groups based on whether they had AIT commenced as part of their surgical care.
Article Synopsis
- * A case-control study analyzed dimensions of affected sphenoid sinuses in 23 patients, finding that fungal balls were more prevalent in smaller, non-dominant sinuses.
- * Post-surgery, all patients showed improved sinus function with no complications, emphasizing the effectiveness of surgical reshaping for managing the condition.
Background: Sinonasal epithelial malignancies are uncommon tumours but represent a challenge to treatment given their close proximity to the orbit, brain and cranial nerves. Traditional external surgical approaches have potential for significant functional and cosmetic morbidity. An endoscopic approach provides the surgeon with good access for tumour removal and enables surveillance postoperatively.
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