Publications by authors named "P G Raijmakers"
The introduction of wire-free microcirculatory resistance index from functional angiography (angio-IMR) promises swift detection of coronary microvascular dysfunction, however it has not been properly validated. We sought to validate angio-IMR against invasive IMR and PET derived microvascular resistance (MVR). Moreover, we studied if angio-IMR could aid in the detection of ischemia with non-obstructive coronary arteries (INOCA).
View Article and Find Full Text PDFMicrovascular resistance reserve in relation to total and vessel-specific atherosclerotic burden.
Eur Heart J Cardiovasc Imaging
November 2024
Aims: The relationship between coronary artery atherosclerosis and microvascular resistance remains unclear. This study aims to clarify the relationship between total atherosclerotic and vessel-specific atherosclerotic burden and microvascular resistance reserve (MRR).
Methods And Results: In this post-hoc analysis of the PACIFIC 1 trial, symptomatic patients without prior coronary artery disease (CAD) underwent [15O]H2O positron emission tomography, coronary computed tomography angiography (CCTA) and invasive fractional flow reserve (FFR).
Article Synopsis
- The study aimed to compare the effectiveness of Coronary Computed Tomography Angiography (CCTA) alone and in combination with Computed Tomography Perfusion (CTP) for detecting in-stent restenosis (ISR).
- After reviewing over 18,000 studies, researchers included 20 relevant studies in their meta-analysis, focusing on those that used advanced 64-slice CT technology.
- Results showed that both CCTA and CCTA + CTP had high diagnostic accuracy for ISR, suggesting these imaging methods should be used regardless of a patient's previous stent placement.
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity.
View Article and Find Full Text PDFArticle Synopsis
- - The study evaluates the effectiveness of quantitative perfusion cardiac magnetic resonance (QP-CMR) imaging in detecting significant coronary artery disease (CAD) in patients with a history of CAD and new chest pain, comparing it with visual assessment of stress perfusion CMR and quantitative PET imaging.
- - Involving 145 patients with prior heart issues, the research found QP-CMR's sensitivity at 66%, which is lower than PET at 80%, but its specificity is on par with both v-CMR and PET at about 60-63%.
- - Overall, the study concludes that QP-CMR's diagnostic performance is similar to that of both other imaging methods for identifying hemodynamically significant CAD, defined by fractional