Publications by authors named "P G Piatti"
Purpose: We explored the accuracy of a urine-based epigenetic test for detecting upper tract urothelial carcinoma.
Materials And Methods: Under an Institutional Review Board-approved protocol, urine samples were prospectively collected from primary upper tract urothelial carcinoma patients before radical nephroureterectomy, ureterectomy, or ureteroscopy between December 2019 and March 2022. Samples were analyzed with Bladder CARE, a urine-based test that measures the methylation levels of 3 cancer biomarkers (TRNA-Cys, SIM2, and NKX1-1) and 2 internal control loci using methylation-sensitive restriction enzymes coupled with quantitative polymerase chain reaction.
Aim/hypothesis: Hepatic insulin resistance (HIR) is considered to be an independent predictor of metabolic disorders and plays an important role in systemic inflammation, which contributes to abnormalities in cardiovascular disease (CVD) risk factors. The aim of this study was to investigate the relationship between HIR and new markers of cardiovascular risks, including leptin/adiponectin ratio (L/A), lipoprotein(a) [Lp(a)], and tumor necrosis factor alpha (TNF-α), at comparable whole body insulin sensitivity in non-diabetic individuals with or without CVD and at high risk of developing type 2 diabetes.
Methods: The HIR index, L/A, Lp(a), and TNF-α were measured in 50 participants with CVD and in 200 without CVD (1:4 ratio).
Article Synopsis
- - Bladder cancer (BC) is the 5th most common cancer in the USA, with non-muscle invasive cases making up 70% of instances; however, high recurrence and progression rates require intensive and invasive monitoring, which can be burdensome for patients and the healthcare system.
- - The Bladder CARE test was developed to detect BC non-invasively through urine samples, achieving a high sensitivity of 93.5% and specificity of 92.6% by analyzing DNA methylation of specific biomarkers with a low limit of detection.
- - The use of the Bladder CARE test not only offers a less invasive detection method but could also streamline patient monitoring, reduce reliance on cystoscopy and improve early-stage BC detection,
Background & Aims: Excess nutrient supply, such as high fat and high glucose intake, promotes oxidative stress and advanced glycation end products accumulation. Oxidative stress and AGE accumulation cause pathological elevation of arginase activity and pro-inflammatory signaling implicated in endothelial dysfunction. Several studies showed positive effects of l-arginine supplementation in endothelial function but little is currently known about the role of l-arginine as prevention of endothelial dysfunction caused by excessive nutrient supply (overfeeding).
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