A 12-week comparison regarding symptom improvement in an urban university-based outpatient child psychiatry clinic.

To compare the efficacy of pharmacotherapy versus combination pharmacotherapy and psychotherapy for externalizing, conduct, and aggressive behaviors in children aged 6 through 18 years in an urban academic outpatient facility. Data from a child psychiatry outpatient population whose scores were identified as "at risk" or "clinically significant" based on a validated and standardized assessment tool were assessed at baseline and 12 weeks or more after treatment. Conduct symptoms worsened with medication management alone but improved with combination treatment (P < 0.

Genomic analysis of the phosphotransferase system in Clostridium botulinum.

Clostridium botulinum is capable of fermenting carbohydrates, but there have been no detailed studies of the uptake of sugars and related substrates. In bacteria, a common and often predominant system of carbohydrate uptake is the phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS). This multi-protein complex catalyses a group translocation involving both uptake and phosphorylation of carbohydrates, and is also known to play an important role in environmental sensing and metabolic regulation.

Proteomic analysis of a distilling strain of Saccharomyces cerevisiae during industrial grain fermentation.

The fermentation performance of industrial yeast strains is influenced, among other things, by their genetic composition and the nature of the fermentable sugar, availability of nitrogen, and temperature. Therefore, to manipulate the fermentation process, it is important to understand, at a molecular level, the changes occurring in the yeast cell throughout industrial fermentation processes. With this aim in mind, using two-dimensional gel electrophoresis and matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS), we have examined the proteome of distillers yeast in an industrial context.

A novel bacteriocin-like substance (BLIS) from a pathogenic strain of Vibrio harveyi.

Inter-strain and inter-species inhibition mediated by a bacteriocin-like inhibitory substance (BLIS) from a pathogenic Vibrio harveyi strain VIB 571 was demonstrated against four isolates of the same species, and one culture each of a Vibrio sp., Vibrio fischeri, Vibrio gazogenes and Vibrio parahaemolyticus. The crude BLIS, which was obtained by ammonium-sulphate precipitation of the cell-free supernatant of a 72 h broth culture of strain VIB 571, was inactivated by lipase, proteinase K, pepsin, trypsin, pronase E, SDS and incubation at > or =60 degrees C for 10 min.

Timing and severity of symptoms associated with the menstrual cycle in a community-based sample in the Midwestern United States.

This study describes the experience of menstruation among normal women, establishing a baseline for comparison with women reporting symptoms of a menstrual disorder. A community-based sample of 900 women kept a daily log of 50 physical, social, and psychological symptoms for a period of time that included two menstrual cycles. Twenty-five items were derived from the DSM-IV criteria for premenstrual dysphoric disorder (PMDD) and 13 from the premenstrual syndrome (PMS) literature.