Publications by authors named "P G McCulloch"
Randomized controlled trials (RCTs) are the cornerstone of modern evidence-based medicine. They are considered essential to establish definitive evidence of efficacy and safety for new drugs, and whenever possible they should also be the preferred method for investigating new high-risk medical devices. Well-designed studies robustly inform clinical practice guidelines and decision-making, but administrative obstacles have made it increasingly difficult to conduct informative RCTs.
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- Musculoskeletal conditions affect 1.71 billion people and are complicated by diverse clinical presentations and unclear biological processes, indicating a need for targeted therapies.
- RNA-based technologies are emerging as a promising treatment approach for joint-related issues such as osteoarthritis and rheumatoid arthritis by leveraging mRNA to enhance protein production that combats inflammation and aids tissue repair.
- This perspective reviews recent research on mRNA therapies, highlighting encouraging preclinical and clinical findings, with the potential to transform treatment strategies for musculoskeletal disorders.
Background And Objective: Randomized clinical trials (RCTs) provide the most reliable estimates of treatment effectiveness for therapeutic interventions. However, flaws in their design and conduct may bias treatment effect estimates, leading to overestimation or underestimation of the true intervention effect. This is especially relevant for complex interventions, such as those in rehabilitation, which are multifaceted and tailored for individual patients or providers, leading to variations in delivery and treatment effects.
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- The study aimed to create and test a report card for endoscopic retrograde cholangiopancreatography (ERCP) to improve audit and feedback, which is less researched compared to tools for procedures like colonoscopy.
- The report card incorporated various indicators for assessing technical performance, adverse events, and patient experiences, with positive feedback from ERCP specialists on its content but concerns over the practicality of gathering detailed data for evaluation.
- Despite challenges in data acquisition, the developed report card shows promise as a useful audit tool, especially with future advancements in video recording and AI technology aiding its implementation in clinical settings.
Surgical treatment of anterior glenohumeral instability: a historical review.
J Shoulder Elbow Surg
December 2024
Background: Glenohumeral instability is a common pathology, particularly in young, active patients.
Methods: A narrative review was performed to describe the history of surgical treatments for anterior shoulder instability.
Results: Open surgical techniques were first described by Bankart in 1923.