Publications by authors named "P G Kirchhoff"
: The general use of triclosan-coated suture material (TCSM) for wound closure to prevent surgical site infections (SSIs) remains controversial. There is no conclusive evidence in the literature to support this and recommendations by professional organizations are contradictory. Therefore, the main objective of the study was to evaluate the 30-day rate of surgical site infections (SSIs) after elective open abdominal surgery using triclosan-coated versus uncoated running sutures (NCSM) for skin closure.
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- Immune checkpoint blockade (ICB) can induce tumor ferroptosis, but many patients don't respond because tumors evade this process within the tumor microenvironment (TME).
- Researchers found that SLC13A3 acts as a transporter for itaconate in tumor cells, contributing to resistance against ferroptosis, which weakens tumor immunity and reduces ICB effectiveness.
- Targeting SLC13A3 through various methods, like genetic alteration or using a specific inhibitor, can sensitize tumors to ferroptosis, slow down tumor growth, and enhance the effectiveness of ICB treatments, highlighting SLC13A3 as a potential target for cancer therapy.
STAT6 is an attractive therapeutic target for human cancers and other human diseases. Starting from a STAT6 ligand with = 3.5 μM binding affinity, we obtained AK-068 with = 6 nM to STAT6 and at least >85-fold binding selectivity over STAT5.
View Article and Find Full Text PDFIntroduction: Surgical treatment of type I hiatal sliding hernias aims to control the gastroesophageal reflux symptoms and prevention of hernia recurrence. Usually, a cruroplasty is performed to narrow the hiatal orifice. Here, it remains controversial if a mesh reinforcement of the cruroplasty should be performed, since benefits as well as mesh-associated complications have been described.
View Article and Find Full Text PDFObjective: We aimed to characterize several aspects of retinal vascular dynamics in a patient with arrythmia in order to elicit additional diagnostic information on microvascular dysfunction.
Methods: A 68-year-old male patient with arrythmia and an age- and gender-matched control subject underwent ocular examination including dynamic retinal vessel assessment with flicker light provocation. Retinal vessel diameters were measured continuously following a standard protocol (IMEDOS Systems, Jena, Germany).