Publications by authors named "P G Jacob"
Skeletal dysplasias are a clinically and genetically heterogeneous group of rare disorders. Studies from large cohorts are essential to provide insights into the disease epidemiology, phenotypic spectrum, and mutational profiles. Here we enumerate additional 248 Indians from 197 families with a skeletal dysplasia, following a similar study earlier.
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- The study investigates the unique experiences of parents with autistic adolescents in India, highlighting the challenges faced during this developmental phase in the context of limited support services.
- Through in-depth interviews, three main themes emerged: a mix of acceptance and grief related to their child's condition, transformational growth resulting from their experiences, and worries about future care due to a lack of systemic support.
- The findings suggest that while families are adapting to their circumstances, there is a significant need for improved support systems and resources to better meet the needs of both autistic individuals and their caregivers throughout their lifespan.
Article Synopsis
- This study introduces a microfluidic device designed to efficiently separate white blood cells (WBCs) from red blood cells (RBCs) for the Nitroblue Tetrazolium (NBT) bioassay, which measures phagocytic activity in cells.
- The device successfully removes 99.99% of RBCs from WBC samples, improving the RBC to WBC ratio from 848:1 to 2:3, and is effective even at a hematocrit concentration of 1% blood.
- The microfluidic device is easy to fabricate, cost-effective, and can process a single drop of blood in under 10 minutes, without the need for complex methods like RBC lysis or expensive