Publications by authors named "P G Hariprasad"

Designing a suitable, cost-effective nanocarrier with an ability to capture and deliver antibiotics for restricting microbial spread remains an unmet need. A simple two-stepped strategy involving citric acid-induced hydrolysis of cellulose pulp (NFC) followed by TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical) mediated oxidation to obtain carboxylated nano fibrillated cellulose (TNFC-5) with high carboxyl content (1.12 mmol/g) has been explored.

View Article and Find Full Text PDF

The need for new antidiabetic drugs is evident, considering the ongoing global burden of type-2 diabetes mellitus despite notable progress in drug discovery from laboratory research to clinical application. This study aimed to build machine learning (ML) models to predict potential α-glucosidase inhibitors based on the data set comprising over 537 reported plant secondary metabolite (PSM) α-glucosidase inhibitors. We assessed 35 ML models by using seven different fingerprints.

View Article and Find Full Text PDF

Withania coagulans (WC) is used in traditional and Ayurveda medicine to treat various ailments, including diabetes. Our investigation found that WC fruit hexane extract effectively suppresses α-glucosidase activity (IC = 0.013 mg/ml, K = 0.

View Article and Find Full Text PDF

Inappropriate antibiotic use not only amplifies the threat of antimicrobial resistance (AMR), moreover exacerbates the spread of resistant bacterial strains and genes in the environment, underscoring the critical need for effective research and interventions. Our aim is to assess the prevalence and resistance characteristics of β-lactam resistant bacteria (BLRB) and β-lactamase resistant bacterial genes (BLRBGs) under various environmental conditions within Delhi NCR, India. Using a culture-dependent method, we isolated 130 BLRB from 75 different environmental samples, including lakes, ponds, the Yamuna River, agricultural soil, aquatic weeds, drains, dumping yards, STPs, and gaushalas.

View Article and Find Full Text PDF

Ethnopharmacological Relevance: India's ancient texts, the Charak Samhita and Sushruta Samhita, make reference to the traditional medicinal usage of Acorus calamus L. In India and China, it has long been used to cure stomach aches, cuts, diarrhea, and skin conditions. This ability of the rhizome is attributed to its antimicrobial properties.

View Article and Find Full Text PDF